Dimethyl Sulfoxide → HCID 67359436, compound

HRID 2065693Notes

Reaction equation

HRID 2065693 reaction equation
Cl[C:2]1[C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]2[C:4](=[C:5]([Cl:16])[CH:6]=[C:7]([Cl:15])[CH:8]=2)[N:3]=1.C[NH:18][C@H:19]([C:30]([OH:32])=[O:31])[CH2:20][C:21]1[C:29]2[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=2)[NH:23][CH:22]=1.[CH3:33]S(C)=O>>[C:30]([C@@H:19]([NH:18][C:2]1[C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]2[C:4](=[C:5]([Cl:16])[CH:6]=[C:7]([Cl:15])[CH:8]=2)[N:3]=1)[CH2:20][C:21]1[C:29]2[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=2)[N:23]([CH3:33])[CH:22]=1)([OH:32])=[O:31]

Participants

4

Reactant 3

HCID 679Dimethyl SulfoxideHCID 160511N-methyl-L-tryptophanHCID 866563792,6,8-Trichloroquinoline-3-carboxylic acid

Product 1

HCID 67359436HCID 67359436, compound

Procedure

In close analogy to the procedure described in Example 1, 2,6,8-trichloroquinoline-3-carboxylic acid is reacted with N-methyl-L-tryptophan in DMSO to provide the title compound in good yield.

Sources & evidence

ORD record
ord-bb81ad60ed5e4055a900cb19dc848c12
Source dataset
uspto-grants-2012_10
Patent number
US08288549B2

Reaction notes

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