HuagongsheHuagongshe Chemistry Print Report · For research reference only
alpha-Bromo-2-nitrotoluene → 4-(3,5-Dichloropyridin-4-ylamino)-7-methoxy-8-(2-nitrobenzyloxy)-2H-chromen-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | alpha-Bromo-2-nitrotoluene | HCID 77569 | — |
| Reactant | 4-(3,5-dichloropyridin-4-ylamino)-8-hydroxy-7-methoxy-2H-chromen-2-one | HCID 24849570 | — |
| Product | 4-(3,5-Dichloropyridin-4-ylamino)-7-methoxy-8-(2-nitrobenzyloxy)-2H-chromen-2-one | HCID 24849619 | — |
Reaction Steps
The title compound was prepared from 1-(bromomethyl)-2-nitrobenzene and 4-(3,5-dichloropyridin-4-ylamino)-8-hydroxy-7-methoxy-2H-chromen-2-one (Example 29) following the procedure outlined in Example 25. 1H NMR (400 MHz, DMSO-d6): δ 9.55 (s, 1H), 8.81 (s, 2H), 8.12 (dd, 1H), 8.05 (d, 1H), 7.99 (d, 1H), 7.82 (td, 1H), 7.62 (td, 1H), 7.22 (d, 1H), 5.43 (s, 2H), 4.65 (s, 1H), (s, 3H); MS (ESI): 487.8.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07745646B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-2368540727ac493499694681824ec6a1 |
| Source note | uspto-grants-2010_06 |