HCID 15342932, compound → HCID 67358315, compound

HRID 2065701Notes

Reaction equation

HRID 2065701 reaction equation
Cl[C:2]1[C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:15])[CH:8]=2)[N:3]=1.[CH3:16][O:17][CH2:18][CH2:19][O:20][C:21](=[O:31])[C@@H:22]([NH2:30])[CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>>[Cl:15][C:7]1[CH:8]=[C:9]2[C:4](=[CH:5][CH:6]=1)[N:3]=[C:2]([NH:30][C@H:22]([C:21]([O:20][CH2:19][CH2:18][O:17][CH3:16])=[O:31])[CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)[C:11]([C:12]([OH:14])=[O:13])=[CH:10]2

Participants

3

Reactant 2

HCID 15342932HCID 15342932, compoundHCID 242660682,6-Dichloroquinoline-3-carboxylic acid

Product 1

HCID 67358315HCID 67358315, compound

Procedure

In close analogy to the procedure described in Example 43, 2,6-dichloro-quinoline-3-carboxylic acid is reacted with (S)-2-amino-3-phenyl-propionic acid 2-methoxy-ethyl ester to provide after chromatographical separation the title compound in moderate yield.

Workup

  1. customto provide
  2. customafter chromatographical separation the title compound in moderate yield

Sources & evidence

ORD record
ord-c244c1d0177a490193cdac15f586d961
Source dataset
uspto-grants-2012_10
Patent number
US08288549B2

Reaction notes

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