HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,6-Dichloroquinoline-3-carboxylic acid → HCID 67357380, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,6-Dichloroquinoline-3-carboxylic acid | HCID 24266068 | — |
| Reactant | HCID 67358437 | HCID 67358437 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | HCID 67357380 | HCID 67357380 | — |
Reaction Steps
In close analogy to the procedure described in Example 1, 2,6-dichloroquinoline-3-carboxylic acid is reacted with 2-amino-3-(3,5-difluoro-phenyl)-succinic acid [prepared by analogy to J. Med. Chem. 1973, 16, 1277-1280.; using alkylation of diethyl acetamidomalonate by methyl bromo-(3,5-difluoro-phenyl)-acetate] in DMSO to provide the title compound in good yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08288549B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-d18fdf82451342c7a2cf78bffe95b24c |
| Source note | uspto-grants-2012_10 |