2,6-Dichloroquinoline-3-carboxylic acid → HCID 67358329, compound

HRID 2065706Notes

Reaction equation

HRID 2065706 reaction equation
Cl[C:2]1[C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:15])[CH:8]=2)[N:3]=1.[CH3:16][N:17]([CH3:32])[CH2:18][CH2:19][O:20][C:21](=[O:31])[CH:22]([NH2:30])[CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][N:25]=1>>[Cl:15][C:7]1[CH:8]=[C:9]2[C:4](=[CH:5][CH:6]=1)[N:3]=[C:2]([NH:30][CH:22]([C:21]([O:20][CH2:19][CH2:18][N:17]([CH3:16])[CH3:32])=[O:31])[CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][N:25]=1)[C:11]([C:12]([OH:14])=[O:13])=[CH:10]2

Participants

3

Reactant 2

HCID 242660682,6-Dichloroquinoline-3-carboxylic acidHCID 67359353HCID 67359353, compound

Product 1

HCID 67358329HCID 67358329, compound

Procedure

In close analogy to the procedure described in Example 43, 2,6-dichloro-quinoline-3-carboxylic acid is reacted with 2-amino-3-pyridin-2-yl-propionic acid 2-dimethylamino-ethyl ester to provide after chromatographical separation the title compound in moderate yield.

Workup

  1. customto provide
  2. customafter chromatographical separation the title compound in moderate yield

Sources & evidence

ORD record
ord-00e8b94521db47fd90e8a2adb5aafb08
Source dataset
uspto-grants-2012_10
Patent number
US08288549B2

Reaction notes

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