3-Pyridin-2-yl-L-alanine → HCID 45256701, compound

HRID 2065717Notes

Reaction equation

HRID 2065717 reaction equation
Cl[C:2]1[C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:15])[CH:8]=2)[N:3]=1.[NH2:16][CH:17]([CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][N:23]=1)[C:18]([OH:20])=[O:19]>CS(C)=O>[C:18]([CH:17]([NH:16][C:2]1[C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:15])[CH:8]=2)[N:3]=1)[CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][N:23]=1)([OH:20])=[O:19]

Participants

4

Reactant 2

HCID 42104063-Pyridin-2-yl-L-alanineHCID 242660682,6-Dichloroquinoline-3-carboxylic acid

Product 1

HCID 45256701HCID 45256701, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

In close analogy to the procedure described in Example 1, 2,6-dichloroquinoline-3-carboxylic acid is reacted with 2-amino-3-pyridin-2-yl-propionic acid in DMSO to provide the title compound in good yield.

Sources & evidence

ORD record
ord-c6ce8f5287f44c179991710dc57f2ee2
Source dataset
uspto-grants-2012_10
Patent number
US08288549B2

Reaction notes

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