Phenylalanine anilide → HCID 67357287, compound

HRID 2065719Notes

Reaction equation

HRID 2065719 reaction equation
Cl[C:2]1[C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:15])[CH:8]=2)[N:3]=1.[NH2:16][C@@H:17]([CH2:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)[C:18]([NH:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)=[O:19]>CS(C)=O>[Cl:15][C:7]1[CH:8]=[C:9]2[C:4](=[CH:5][CH:6]=1)[N:3]=[C:2]([NH:16][C@H:17]([C:18](=[O:19])[NH:20][C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1)[CH2:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)[C:11]([C:12]([OH:14])=[O:13])=[CH:10]2

Participants

4

Reactant 2

HCID 151952Phenylalanine anilideHCID 242660682,6-Dichloroquinoline-3-carboxylic acid

Product 1

HCID 67357287HCID 67357287, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

In close analogy to the procedure described in Example 1, 2,6-dichloroquinoline-3-carboxylic acid is reacted with (S)-2-amino-3,N-diphenyl-propionamide in DMSO to provide the title compound in moderate yield.

Sources & evidence

ORD record
ord-528d0a76406e417da525225127ab0a52
Source dataset
uspto-grants-2012_10
Patent number
US08288549B2

Reaction notes

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