HCID 7315566, compound → HCID 45256704, compound

HRID 2065721Notes

Reaction equation

HRID 2065721 reaction equation
Cl[C:2]1[C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:15])[CH:8]=2)[N:3]=1.[NH2:16][C@@H:17]([CH2:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)[C:18]([NH:20][CH2:21][CH2:22][OH:23])=[O:19]>CS(C)=O>[Cl:15][C:7]1[CH:8]=[C:9]2[C:4](=[CH:5][CH:6]=1)[N:3]=[C:2]([NH:16][C@H:17]([C:18](=[O:19])[NH:20][CH2:21][CH2:22][OH:23])[CH2:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)[C:11]([C:12]([OH:14])=[O:13])=[CH:10]2

Participants

4

Reactant 2

HCID 7315566HCID 7315566, compoundHCID 242660682,6-Dichloroquinoline-3-carboxylic acid

Product 1

HCID 45256704HCID 45256704, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

In close analogy to the procedure described in Example 1, 2,6-dichloroquinoline-3-carboxylic acid is reacted with (S)-2-amino-N-(2-hydroxy-ethyl)-3-phenyl-propionamide [JACS 1969, 91, 2684-2691.] in DMSO to provide the title compound in good yield.

Sources & evidence

ORD record
ord-c3cce91de6f243318dcd0e20f3021286
Source dataset
uspto-grants-2012_10
Patent number
US08288549B2

Reaction notes

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