L-Tryptophan → HCID 67361030, compound

HRID 2065723Notes

Reaction equation

HRID 2065723 reaction equation
Cl[C:2]1[C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]2[C:4](=[C:5]([Cl:16])[CH:6]=[C:7]([Cl:15])[CH:8]=2)[N:3]=1.[NH2:17][C@H:18]([C:29]([OH:31])=[O:30])[CH2:19][C:20]1[C:28]2[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=2)[NH:22][CH:21]=1>CS(C)=O>[C:29]([C@@H:18]([NH:17][C:2]1[C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]2[C:4](=[C:5]([Cl:16])[CH:6]=[C:7]([Cl:15])[CH:8]=2)[N:3]=1)[CH2:19][C:20]1[C:28]2[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=2)[NH:22][CH:21]=1)([OH:31])=[O:30]

Participants

4

Reactant 2

HCID 6305L-TryptophanHCID 866563792,6,8-Trichloroquinoline-3-carboxylic acid

Product 1

HCID 67361030HCID 67361030, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

In close analogy to the procedure described in Example 1, 2,6,8-trichloroquinoline-3-carboxylic acid is reacted with L-tryptophan in DMSO to provide the title compound in good yield.

Sources & evidence

ORD record
ord-b607f4dcb37c4233b7a7db0dbdfc0464
Source dataset
uspto-grants-2012_10
Patent number
US08288549B2

Reaction notes

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