Methanol → HCID 68730046, compound

Participants

Reaction Steps

To a solution of 4-(3-chloro-benzenesulfonyl)-1-(4-fluoro-2-methyl-phenyl)-piperazine-2-carboxylic acid ethyl ester (730 mg) in tetrahydrofuran (20 mL) was added 1 M aqueous LiOH solution (16.6 mL) and methanol until a clear solution was obtained. The mixture was stirred at reflux for 1 h, 1M KHSO4 (20 mL) was added and the inorganic phase was extracted with ethyl acetate. The combined organic phases were dried (Na2SO4), filtered and evaporated to yield 4-(3-chloro-benzenesulfonyl)-1-(4-fluoro-2-methyl-phenyl)-piperazine-2-carboxylic acid as a light yellow solid, MS: 411.0 ([M−H, 1Cl]−).

Provenance & Evidence