HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 68729916, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 3-Methoxybenzenesulfonyl chloride | HCID 2737504 | — |
| Reactant | Ethyl 1-benzylpiperazine-2-carboxylate | HCID 10682021 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 68729916 | HCID 68729916 | 82.5% |
Reaction Steps
A solution of 1-benzyl-piperazine-2-carboxylic acid ethyl ester (300 mg) in DMF (13 mL) was treated with triethylamine (0.5 mL) and 3-methoxybenzene sulfonyl chloride (274.6 mg) at RT for 2 hours. Water was added, and the inorganic layer was extracted with ethyl acetate (×3). The combined organic layers were dried (Na2SO4), filtered and evaporated to yield 1-benzyl-4-(3-methoxy-benzenesulfonyl)-piperazine-2-carboxylic acid ethyl ester as a colorless oil (417 mg), MS: 419.3 ([M+H]+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08288541B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-0c648ddc0767433e97bc63a0ecd86b93 |
| Source note | uspto-grants-2012_10 |