Hydrochloric Acid → HCID 68729707, compound

Participants

Reaction Steps

To a solution of 4-(3-chloro-benzenesulfonyl)-2-[4-(2,5-dimethyl-phenyl)-piperazine-1-carbonyl]-piperazine-1-carboxylic acid tert-butyl ester (2.18 g) in ethanol (21.8 mL) was added a saturated solution of HCl in ethanol (21.8 mL) at 0° C. The reaction mixture was stirred at ambient temperature overnight, the solution was concentrated and the residue dissolved in a mixture of NaHCO3 solution and ethyl acetate. The inorganic phase was extracted with ethyl acetate (×3) and the combined organic layers were washed with brine, dried (Na2SO4), filtered and evaporated to yield [4-(3-chloro-benzenesulfonyl)-piperazin-2-yl]-[4-(2,5-dimethyl-phenyl)-piperazin-1-yl]-methanone as crude product (1.79 g), MS: 477.0 ([M+H, 1Cl]+).

Provenance & Evidence