Water → HCID 25186174, compound

Participants

Reaction Steps

[4-(3-Chloro-benzenesulfonyl)-1-(4-fluoro-2-methyl-phenyl)-piperazin-2-yl]-piperazin-1-yl-methanone (60 mg), 3-chloro-2,5-dimethylpyrazine (18.1 μL) and triethylamine (20.8 μL) in acetonitrile (1 mL) were heated to 170° C. in the microwave. Water was added and the reaction mixture was extracted with ethyl acetate. The combined organic phases were washed with brine, dried (Na2SO4), filtered and evaporated. Purification by chromatography (SiO2, n-heptane/ethyl acetate 1:2) gave [4-(3-chloro-benzenesulfonyl)-1-(4-fluoro-2-methyl-phenyl)-piperazin-2-yl]-(3′,6′-dimethyl-2,3,5,6-tetrahydro-[1,2′]bipyrazinyl-4-yl)-methanone as a yellow oil, MS: 587.3 ([M+H, 1Cl]+).

Provenance & Evidence