Formaldehyde → HCID 25186726, compound

HRID 2065771Notes

Reaction equation

HRID 2065771 reaction equation
Cl.[CH3:2][C:3]1[CH:8]=[CH:7][C:6]([CH3:9])=[CH:5][C:4]=1[N:10]1[CH2:15][CH2:14][N:13]([C:16]([C@@H:18]2[C@H:23]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[CH2:22][CH2:21][NH:20][CH2:19]2)=[O:17])[CH2:12][CH2:11]1.[Cl:30][C:31]1[CH:32]=[C:33]([S:37](Cl)(=[O:39])=[O:38])[CH:34]=[CH:35][CH:36]=1.C=O>>[Cl:30][C:31]1[CH:32]=[C:33]([S:37]([N:20]2[CH2:21][CH2:22][C@@H:23]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[C@@H:18]([C:16]([N:13]3[CH2:12][CH2:11][N:10]([C:4]4[CH:5]=[C:6]([CH3:9])[CH:7]=[CH:8][C:3]=4[CH3:2])[CH2:15][CH2:14]3)=[O:17])[CH2:19]2)(=[O:39])=[O:38])[CH:34]=[CH:35][CH:36]=1

Participants

4

Reactant 3

HCID 712FormaldehydeHCID 179093-Chlorobenzenesulphonyl chlorideHCID 68728469HCID 68728469, compound

Product 1

HCID 25186726HCID 25186726, compound

Procedure

In analogy to example 1, step 3, from [4-(2,5-dimethyl-phenyl)-piperazin-1-yl]-((3R,4R)-4-phenyl-piperidin-3-yl)-methanone hydrochloride and 3-chlorobenzene-sulfonyl chloride was prepared [(3R,4R)-1-(3-chloro-benzenesulfonyl)-4-phenyl-piperidin-3-yl]-[4-dimethyl-phenyl)-piperazin-1-yl]-methanone as a white foam, MS: 552.2 ([M+H, 1Cl])+.

Sources & evidence

ORD record
ord-1e796111060a408aa6bcfe57c4331ddf
Source dataset
uspto-grants-2012_10
Patent number
US08288541B2

Reaction notes

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