Pyridine-3-sulfonyl chloride hydrochloride → HCID 25188121, compound

Participants

Reaction Steps

In analogy to example 63, step 4, from (3S,4R) or (3R,4S)-[4-(5-chloro-2-methyl-phenyl)-piperazin-1-yl]-[4-(2,4-difluoro-phenyl)-piperidin-3-yl]-methanone hydrochloride and pyridine-3-sulfonyl chloride hydrochloride was prepared (3S,4R) or (3R,4S)-[4-(5-chloro-2-methyl-phenyl)-piperazin-1-yl]-[(3S,4R)-4-(2,4-difluoro-phenyl)-1-(pyridine-3-sulfonyl)-piperidin-3-yl]-methanone as a white foam, MS: 575.4 ([M+H, 1Cl])+; [α]D=−66.76 (c=0.454 g/100 mL, CHCl3).

Provenance & Evidence