HCID 58249669, compound → N-(5-Chloro-2-methylphenyl)piperazine

HRID 2065775Notes

Reaction equation

HRID 2065775 reaction equation
C(OC(N1CC[C@H](C2C=CC=CC=2)[C@H](C(O)=O)C1)=O)(C)(C)C.C(OC(N1CC[C@H](C2C=CC=CC=2)[C@H](C([N:44]2[CH2:49][CH2:48][N:47]([C:50]3[CH:55]=[C:54]([Cl:56])[CH:53]=[CH:52][C:51]=3[CH3:57])[CH2:46][CH2:45]2)=O)C1)=O)(C)(C)C>>[Cl:56][C:54]1[CH:53]=[CH:52][C:51]([CH3:57])=[C:50]([N:47]2[CH2:46][CH2:45][NH:44][CH2:49][CH2:48]2)[CH:55]=1

Participants

3

Reactant 2

HCID 58249669HCID 58249669, compoundHCID 68960949HCID 68960949, compound

Product 1

HCID 693767N-(5-Chloro-2-methylphenyl)piperazine

Procedure

In analogy to example 1, step 1, from (3S,4S)-4-phenyl-piperidine-1,3-dicarboxylic acid 1-tert-butyl ester (CAS Reg. No.: [197900-77-9]) and 1-(5-chloro-2-methylphenyl)-piperazine was prepared (3S,4S)-3-[4-(5-chloro-2-methyl-phenyl)-piperazine-1-carbonyl]-4-phenyl-piperidine-1-carboxylic acid tert-butyl ester as a white foam, MS: 498.5 ([M+H, 1Cl])+.

Sources & evidence

ORD record
ord-52c48bfb8e814d6ea136907b42293a2e
Source dataset
uspto-grants-2012_10
Patent number
US08288541B2

Reaction notes

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