HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloroform → 3-Chlorobenzenesulphonyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloroform | HCID 6212 | — |
| Reactant | HCID 68960740 | HCID 68960740 | — |
| Reactant | [4-(5-Chloro-2-methyl-phenyl)-piperazin-1-yl]-methanone | HCID 86627852 | — |
| Product | 3-Chlorobenzenesulphonyl chloride | HCID 17909 | — |
| Product | Methanone hydrochloride | HCID 19933572 | — |
Reaction Steps
In analogy to example 63, step 4, from [4-(5-chloro-2-methyl-phenyl)-piperazin-1-yl]-[(3S,4S) or (3R,4R)-4-(4-fluoro-2-methyl-phenyl)-piperidin-3-yl]-methanone hydro-chloride and 3-chlorobenzenesulfonyl chloride was prepared [(3S,4S) or (3R,4R)-1-(3-chloro-benzenesulfonyl)-4-(4-fluoro-2-methyl-phenyl)-piperidin-3-yl]-[4-(5-chloro-2-methyl-phenyl)-piperazin-1-yl]-methanone as a white foam, MS: 604.0 ([M+H, 1Cl])+; [α]D=−32.13 (c=0.426 g/100 mL, CHCl3).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08288541B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-cf8c17a06fbe4451876626af6fb33c33 |
| Source note | uspto-grants-2012_10 |