HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloroform → 3-Chlorobenzenesulphonyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloroform | HCID 6212 | — |
| Reactant | HCID 68960740 | HCID 68960740 | — |
| Reactant | [4-(5-Chloro-2-methyl-phenyl)-piperazin-1-yl]-methanone | HCID 86627852 | — |
| Product | 3-Chlorobenzenesulphonyl chloride | HCID 17909 | — |
| Product | Methanone hydrochloride | HCID 19933572 | — |
Reaction Steps
In analogy to example 63, step 4, from 4-(5-chloro-2-methyl-phenyl)-piperazin-1-yl]-[(3S,4S) or (3R,4R)-4-(2,4-difluoro-phenyl)-piperidin-3-yl]-methanone hydrochloride and 3-chlorobenzenesulfonyl chloride was prepared [(3S,4S) or (3R,4R)-1-(3-chloro-benzenesulfonyl)-4-(2,4-difluoro-phenyl)-piperidin-3-yl]-[4-(5-chloro-2-methyl-phenyl)-piperazin-1-yl]-methanone as a white foam, MS: 608.0 ([M+H, 1Cl])+; [α]D=+10.71 (c=0.392 g/100 mL, CHCl3).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08288541B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-f8fceb29573a43f882c1fe15805d9a6c |
| Source note | uspto-grants-2012_10 |