HCID 178500118, compound → HCID 178500115, compound

Participants

Reaction Steps

A mixture of methyl 2-[5-(2,4-difluorophenyl)-4-(6-hydroxy-5-nitro-2-pyridyl)-1H-imidazol-2-yl]-2-methyl-propanoate (49.5 g, 118.32 mmol) and palladium 5% weight (dry basis) on activated carbon (4.95 g, 2.33 mmol) in methanol (1.18 L) is stirred under a hydrogen atmosphere (balloon) at RT overnight. The suspension is filtered through CELITE®, rinsed with methanol, and the filtrate is concentrated under reduced pressure to afford the crude title compound (39 g) as a brown solid.

Provenance & Evidence