HCID 178526541, compound → HCID 178507437, compound

Participants

Reaction Steps

6-[2-Cyclopropyl-5-(2,4-difluorophenyl)-1H-imidazol-4-yl]-3-nitro-pyridin-2-ol (4.525 g, 12.63 mmol) is dissolved in ethanol (63 mL). The solution is degassed with bubbling nitrogen gas. 10% Pd/C (920 mg) is added portionwise to the mixture and the mixture is saturated with hydrogen. The mixture is stirred under a hydrogen atmosphere (balloon) at RT over the weekend, at which time LC/MS shows complete conversion. The suspension is filtered through a pad of CELITE® to remove the catalyst and the solution is concentrated under reduced pressure to afford the title compound (3.97 g, 89%). LC-ES/MS m/z 328.9 (M+1).

Provenance & Evidence