Hydrochloric Acid → HCID 178495117, compound

Participants

Reaction Conditions

Reaction Steps

To a slightly pink suspension of 2-[5-(2,4-difluorophenyl)-4-[2-[[(1S)-3-methoxy-1-methyl-propyl]amino]oxazolo[5,4-b]pyridin-5-yl]-1H-imidazol-2-yl]-2-methyl-propan-1-ol (25.7 g, 54.51 mmol) in methyl tert-butyl ether (771 mL) at 60° C., is added a 4.0 M HCl solution in dioxane (16.35 mL, 65.41 mmol). The resulting suspension is heated to 60° C. for 30 min and then allowed to reach RT gradually. A solid is formed and is filtered under an inert atmosphere of nitrogen and quickly collected and dried under vacuum at 60° C. overnight to provide the title compound as a creamy solid (27 g, 98%). LC-ES/MS m/z 472 (M+1).

Provenance & Evidence