反应详情

温度

50 °C

Prepared in accordance with Method B with methyl isocyanoacetate (1.00 g, 10.10 mmol) and dihydro-1H-pyrrole (1.01 mL, 15.15 mmol). The reaction mixture was stirred 5 h at 50° C. and concentrated. The residue was dissolved in dichloromethane (50 mL) and the organic layer was washed with 10% aqueous citric acid (2×25 mL), dried over MgSO4, filtered and evaporated. 2-Isocyano-1-(2H-pyrrol-1(5H)-yl)ethanone SLA 07178 was obtained (1.0 g, 73% yield) as a yellow solid.

1. concentrationconcentrated
2. dissolutionThe residue was dissolved in dichloromethane (50 mL)
3. washthe organic layer was washed with 10% aqueous citric acid (2×25 mL)
4. dry with materialdried over MgSO4
5. filtrationfiltered
6. customevaporated