HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Hydroxide → HCID 68955963, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | 3-Thiophenecarboxaldehyde | HCID 68135 | — |
| Reactant | Pyrrolidine, 1-(isocyanoacetyl)- | HCID 6455476 | — |
| Reactant | HCID 68953618 | HCID 68953618 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 68953618 | HCID 68953618 | — |
| Product | HCID 68955963 | HCID 68955963 | 40% |
Reaction Steps
BLE 04124A was prepared in accordance with method D using thiophen-3-carboxaldehyde (0.475 mL, 5.42 mmol), KOH (0.276 mg, 4.92 mmol) in methanol (5 mL) and 2-isocyano-1-(pyrrolidin-1-yl)ethanone BLE 04098 (0.75 g, 5.43 mmol). After work-up the residue obtained was recristallized from ethyl acetate to obtain after filtration trans-(4,5-dihydro-5-(thiophen-3-yl)oxazol-4-yl)(pyrrolidin-1-yl)methanone BLE 04110A as a yellow pale solid (0.498 g, 40% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08288556B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-f1dad9fe629e4346ba0944bba30e9e6b |
| Source note | uspto-grants-2012_10 |