Nicotinic Acid → HCID 58418008, compound

HRID 2065877Notes

Reaction equation

HRID 2065877 reaction equation
[C:1](O)(=O)[C:2]1[CH:7]=CC=N[CH:3]=1.C([O:14][C:15](=[O:25])[C:16]1[CH:21]=[C:20](Cl)[C:19]([CH:23]=[CH2:24])=[N:18][CH:17]=1)(C)(C)C>>[CH2:23]([C:19]1[C:20]([CH2:1][CH:2]([CH3:7])[CH3:3])=[CH:21][C:16]([C:15]([OH:14])=[O:25])=[CH:17][N:18]=1)[CH3:24]

Participants

3

Reactant 2

HCID 938Nicotinic AcidHCID 67026909HCID 67026909, compound

Product 1

HCID 58418008HCID 58418008, compound

Procedure

6-Ethyl-5-isobutyl-nicotinic acid is prepared in analogy to Nicotinic acid 3 from 5-chloro-6-vinyl-nicotinic acid tert.-butyl ester and 2,4,6-tri-(2-methyl-propenyl)cycloboroxane pyridine complex, prepared in analogy to a procedure given by F. Kerins, D. F. O'Shea J. Org. Chem. 67 (2002) 4968-4971); LC-MS: tR=0.64 min, [M+1]+=207.98.

Workup

  1. customprepared in analogy to a procedure

Sources & evidence

ORD record
ord-92845c8c7c544c009f1c705d75a931f1
Source dataset
uspto-grants-2012_10
Patent number
US08288554B2

Reaction notes

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