HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 6-Isobutyl-5-methyl-nicotinic acid hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 6-Isobutyl-5-methylnicotinic acid ethyl ester | HCID 57437200 | — |
| Product | 6-Isobutyl-5-methyl-nicotinic acid hydrochloride | HCID 67027182 | — |
Reaction Steps
A solution of 6-isobutyl-5-methyl-nicotinic acid ethyl ester (3.75 g, 16.95 mmol) in 12.5% aq. HCl (50 mL) is stirred at 65° C. for 24 h before the solvent is evaporated. The residue is dried under HV to give 6-isobutyl-5-methyl-nicotinic acid hydrochloride (3.55 g) as a white powder; LC-MS: tR=0.57 min, [M+1]+=194.25.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08288554B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-80d37490514e4003814634beacaa4c4e |
| Source note | uspto-grants-2012_10 |