HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Nitrobenzyl bromide → 4-(3,5-Dichloropyridin-4-ylamino)-7-methoxy-8-(4-nitrobenzyloxy)-2H-chromen-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Nitrobenzyl bromide | HCID 66011 | — |
| Reactant | 4-(3,5-dichloropyridin-4-ylamino)-8-hydroxy-7-methoxy-2H-chromen-2-one | HCID 24849570 | — |
| Product | 4-(3,5-Dichloropyridin-4-ylamino)-7-methoxy-8-(4-nitrobenzyloxy)-2H-chromen-2-one | HCID 24849621 | — |
Reaction Steps
The title compound was prepared from 1-(bromomethyl)-4-nitrobenzene and 4-(3,5-dichloropyridin-4-ylamino)-8-hydroxy-7-methoxy-2H-chromen-2-one (Example 29) following the procedure outlined in Example 25. 1H NMR (400 MHz, DMSO-d6): δ 9.55 (s, 1H), 8.81 (s, 2H), 8.25 (d, 2H), 7.99 (d, 1H), 7.80 (d, 2H), 7.25 (d, 1H), 5.20 (s, 2H), 4.66 (s, 1H), 3.93 (s, 3H); MS (ESI): 487.8.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07745646B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-7da20564ac7f4eb4b9839fae9834f8f1 |
| Source note | uspto-grants-2010_06 |