反应详情

温度

60 °C

5% palladium on carbon (0.27 g) was added to a solution of (2S,3aR,7aS)-ethyl 1-((S)-1-phenylethyl)octahydro-1H-indole-2-carboxylate (15) (2.7 g) in ethanol (20 mL) and the mixture was heated at 60° C. under hydrogen (14.5 psi) atmosphere for NLT 3 hours. The catalyst was filtered and washed with fresh ethanol (15 mL). The combined filtrate was concentrated under vacuum to afford 1.93 g of (2S,3aR,7aS)-Ethyl octahydro-1H-indole-2-carboxylate (16) as a viscous oil.

1. filtrationThe catalyst was filtered
2. washwashed with fresh ethanol (15 mL)
3. concentrationThe combined filtrate was concentrated under vacuum