Benzyl isocyanate → HCID 58489102, compound

HRID 2065945Notes

Reaction equation

HRID 2065945 reaction equation
[OH:1][CH:2]([CH3:10])/[CH:3]=[CH:4]/[C:5]([O:7][CH2:8][CH3:9])=[O:6].[CH2:11]([N:18]=[C:19]=[O:20])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>C1(C)C=CC=CC=1>[CH2:11]([NH:18][C:19]([O:1][CH:2]([CH3:10])/[CH:3]=[CH:4]/[C:5]([O:7][CH2:8][CH3:9])=[O:6])=[O:20])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

Participants

4

Reactant 2

HCID 76639Benzyl isocyanateHCID 9989379HCID 9989379, compound

Product 1

HCID 58489102HCID 58489102, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

Reaction of 21 (rac-Ethyl (2E)-4-hydroxypent-2-enoate) (1.44 g, 10 mmol) with benzyl isocyanate (1.73 g, 13 mmol) in toluene (8 ml) according to Example 1. Purification by flash chromatography (AcOiPr:heptane fraction 25:75) yields 3 (rac-Ethyl (2E)-4-(benzylaminocarbonyloxy)pent-2-enoate) (2.49 g, 90%) as a with solid.

Workup

  1. customPurification by flash chromatography (AcOiPr:heptane fraction 25:75)

Sources & evidence

ORD record
ord-c0ea1165a33e4e029a8ed8189b986b0c
Source dataset
uspto-grants-2012_10
Patent number
US08288566B2

Reaction notes

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