HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzylamine → HCID 46200115, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzylamine | HCID 7504 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Heptane | HCID 8900 | — |
| Reactant | HCID 131730025 | HCID 131730025 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Ammonia | HCID 222 | — |
| Product | HCID 46200115 | HCID 46200115 | 67% |
Reaction Steps
Reaction of 17 (rac-Ethyl (2E)-4-(diethoxyphosphinyloxy)-2-methylpent-2-enoate) (188 mg, 0.60 mind) with BnNH2 (131 μL, 1.2 mmol) and 5 mol % [Pd] in CH2Cl2 (3.5 ml) at room temperature. MPLC (SiO2 with NH3 deactivated, AcOEt:heptane fraction 20:80) and preparative TLC (NH3-conditioned, AcOEt:heptane fraction 50:50) yield 18 (rac-Ethyl (2E)-N-benzyl-4-amino-2-methylpent-2-enoate) (98.7 mg, 67%) as a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08288566B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-252a29d81c51441d8c03e79c0530958e |
| Source note | uspto-grants-2012_10 |