HuagongsheHuagongshe Chemistry Print Report · For research reference only
P-Anisidine → HCID 131730026, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | P-Anisidine | HCID 7732 | — |
| Reactant | Heptane | HCID 8900 | — |
| Reactant | HCID 131730025 | HCID 131730025 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Isopropyl Acetate | HCID 7915 | — |
| Product | HCID 131730026 | HCID 131730026 | 182.3% |
Reaction Steps
Reaction of 17 (rac-Ethyl (2E)-4-(diethoxyphosphinyloxy)-2-methylpent-2-enoate) (188 mg, 0.60 mmol) with p-anisidine (148 mg, 1.2 mmol) and 5 mol % [Pd] in CH2Cl2 (3.5 ml) at room temperature. Flash chromatography (AcOiPr:heptane fraction 15:85 to 20:80) yields 19 (rac-Ethyl (2E)-N-(4-methoxyphenyl)-4-amino-2-methylpent-2-enoate) (144 mg, 91) as a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08288566B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-408f47280de54cbb8d4cec4d6cf3413b |
| Source note | uspto-grants-2012_10 |