HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2065955Generated: November 2, 2026
Hydrochloric Acid → HCID 131730027, compound
https://huagongshe.com/reaction/2065955
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Ethylamine | HCID 6341 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | (2E)-4-Oxo-2-pentenoic acid | HCID 5363652 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 131730027 | HCID 131730027 | — |
Reaction Steps
(2E)-4-Oxopent-2-enoic acid (9.41 g, 80 mmol) and EtNH2 (2 M in THF, 40 ml, 80 mmol) are dissolved in CH2Cl2 (250 ml). The solution is cooled to 0° C. Then DMAP (1.47 g, 12 mmol) and EDCl (15.34 g, 80 mmol) are added. The resulting suspension is stirred for 17 h at 0 (C. Then the reaction mixture is poured into 2 M HCl (100 ml) and extracted with CH2Cl2 (2×1 l). The organic phases are washed with 2 M HCl (50 ml), saturated NaHCO3 (50 ml) and brine (100 ml) successively. The combined organic phases are dried with Na2SO4 and evaporated under reduced pressure at 40° C. 24 (ethyl (2E)-4-oxopent-2-enamide) (5.74 g, 51%) is obtained as a brown solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08288566B2 |
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| Source dataset | uspto-grants-2012_10 |
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| ORD ID | ord-d1490771ae734707adc9b875c3587121 |
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| Source note | uspto-grants-2012_10 |
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