Acetonitrile, 2-(methylamino)- → HCID 136386925, compound

HRID 2065965Notes

Reaction equation

HRID 2065965 reaction equation
[C:1]([C:5]1[CH:10]=[C:9]([C:11]2[O:12][CH:13]=[C:14]([CH2:16][CH2:17][N:18]([CH3:22])[CH2:19][C:20]#C)[N:15]=2)[CH:8]=[C:7]([C:23]([CH3:26])([CH3:25])[CH3:24])[C:6]=1[OH:27])([CH3:4])([CH3:3])[CH3:2].C[NH:29]CC#N.CNCC#C>>[C:23]([C:7]1[CH:8]=[C:9]([C:11]2[O:12][CH:13]=[C:14]([CH2:16][CH2:17][N:18]([CH2:19][C:20]#[N:29])[CH3:22])[N:15]=2)[CH:10]=[C:5]([C:1]([CH3:3])([CH3:2])[CH3:4])[C:6]=1[OH:27])([CH3:26])([CH3:24])[CH3:25]

Participants

4

Reactant 3

HCID 36652Acetonitrile, 2-(methylamino)-HCID 96160N-methylpropyn-2-ylamineHCID 136386909HCID 136386909, compound

Product 1

HCID 136386925HCID 136386925, compoundYield 36%

Procedure

The experimental protocol used is identical to that described for the compound of Example 26, methylaminoacetonitrile being used as starting product in place of the N-methylpropargylamine. A white solid is obtained with a yield of 36%. Melting point: 165-167.8° C.

Workup

  1. customA white solid is obtained with a yield of 36%

Sources & evidence

ORD record
ord-14b5b7157b0e4374b7af00b39677f4b4
Source dataset
uspto-grants-2012_10
Patent number
US08288560B2

Reaction notes

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