Bromine → HCID 13173168, compound

HRID 2065985Notes

Reaction equation

HRID 2065985 reaction equation
[C:1]([C:5]1[CH:6]=[C:7]([C:16](=[O:19])[CH2:17][CH3:18])[CH:8]=[C:9]([C:12]([CH3:15])([CH3:14])[CH3:13])[C:10]=1[OH:11])([CH3:4])([CH3:3])[CH3:2].[Br:20]Br>C(O)(=O)C>[Br:20][CH:17]([CH3:18])[C:16]([C:7]1[CH:6]=[C:5]([C:1]([CH3:4])([CH3:3])[CH3:2])[C:10]([OH:11])=[C:9]([C:12]([CH3:15])([CH3:14])[CH3:13])[CH:8]=1)=[O:19]

Participants

4

Reactant 2

HCID 24408BromineHCID 6161722,6-Bis(1,1-dimethylethyl)-4-(1-oxopropyl)phenol

Product 1

HCID 13173168HCID 13173168, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

This compound is obtained simply by reacting 1-(3,5-ditert-butyl-4-hydroxyphenyl)propan-1-one (prepared from 2,6-ditertbutylphenol according to Russ. J. Org. Chem. (1997), 33, 1409-1416) with bromine in acetic acid or also according to a protocol described in one of the following references: Biorg. Med. Chem. Lett. (1996), 6(3), 253-258; J. Med. Chem. (1988), 31(10), 1910-1918; J. Am. Chem. Soc. (1999), 121, 24.

Workup

  1. customThis compound is obtained simply

Sources & evidence

ORD record
ord-876900c7ef454a31983aa4e74bb0708f
Source dataset
uspto-grants-2012_10
Patent number
US08288560B2

Reaction notes

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