HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzhydrylamine → 1-benzhydrylazetidin-3-ol Hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzhydrylamine | HCID 7036 | — |
| Reactant | Epichlorohydrin | HCID 7835 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-benzhydrylazetidin-3-ol Hydrochloride | HCID 2801726 | 45% |
Reaction Steps
Aminodiphenylmethane (55 g; 0.3 mol) and epichlorhydrin (23.5 ml; 0.3 mol) are mixed in methanol (200 ml). The mixture is heated under reflux for 5 days. The methanol is then evaporated off in order to produce a beige solid. The latter is filtered and washed with ether in order to produce a white solid with a yield of 45%. Melting point: 186.0-186.4° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08288560B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-b0aafddab3a84566b9c156f10051a700 |
| Source note | uspto-grants-2012_10 |