Propanal → HCID 10110405, compound

HRID 2065993Notes

Reaction equation

HRID 2065993 reaction equation
Cl.[CH:2]1[C:15]2[NH:14][C:13]3[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=3)[S:7][C:6]=2[CH:5]=[CH:4][C:3]=1[C:16]1[N:17]=[C:18]([CH2:21][NH2:22])[S:19][CH:20]=1.[CH3:23][C:24]([CH:27]=O)([CH3:26])[CH3:25].C(=O)CC>>[CH2:23]([NH:22][CH2:21][C:18]1[S:19][CH:20]=[C:16]([C:3]2[CH:4]=[CH:5][C:6]3[S:7][C:8]4[C:13](=[CH:12][CH:11]=[CH:10][CH:9]=4)[NH:14][C:15]=3[CH:2]=2)[N:17]=1)[C:24]([CH3:27])([CH3:26])[CH3:25]

Participants

4

Reactant 3

HCID 527PropanalHCID 12417PivalaldehydeHCID 67213853HCID 67213853, compound

Product 1

HCID 10110405HCID 10110405, compoundYield 40.6%

Procedure

This compound is prepared according to a protocol identical to that described for Stage 399.1 of Example 399, with the compound of Example 362 and pivaldehyde respectively replacing intermediate 355.2 and the propionaldehyde. The expected product is obtained in the form of an off-white solid with a yield of 40.6%. Melting point: 172.0-174.0° C.

Workup

  1. customThis compound is prepared

Sources & evidence

ORD record
ord-efb058b7ff494a96908dea57c7a87cdc
Source dataset
uspto-grants-2012_10
Patent number
US08288560B2

Reaction notes

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