Acetyl chloride → HCID 10271212, compound

HRID 2065994Notes

Reaction equation

HRID 2065994 reaction equation
Cl.[CH:2]1[C:15]2[NH:14][C:13]3[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=3)[S:7][C:6]=2[CH:5]=[CH:4][C:3]=1[C:16]1[N:17]=[C:18]([CH2:21][NH2:22])[S:19][CH:20]=1.[C:23](Cl)(=[O:27])[CH2:24][CH2:25][CH3:26].C(Cl)(=O)C>>[CH:2]1[C:15]2[NH:14][C:13]3[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=3)[S:7][C:6]=2[CH:5]=[CH:4][C:3]=1[C:16]1[N:17]=[C:18]([CH2:21][NH:22][C:23](=[O:27])[CH2:24][CH2:25][CH3:26])[S:19][CH:20]=1

Participants

4

Reactant 3

HCID 6367Acetyl chlorideHCID 8855Butyryl chlorideHCID 67213853HCID 67213853, compound

Product 1

HCID 10271212HCID 10271212, compoundYield 47.2%

Procedure

This compound is prepared according to a protocol identical to that described for Example 355, with the compound of Example 362 and butanoyl chloride respectively replacing intermediate 355.2 and the acetyl chloride in Stage 355.3. The expected product is obtained in the form of a yellow solid with a yield of 47.2%. Melting point: 218.0-220.0° C.

Workup

  1. customThis compound is prepared

Sources & evidence

ORD record
ord-7e3523e8ec8c4605bce17928839e9415
Source dataset
uspto-grants-2012_10
Patent number
US08288560B2

Reaction notes

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