Water → Citalopram

Participants

Reaction Conditions

Reaction Steps

A solution of citalopram hydrobromide (200 Kg, 0.49 kmoles), in toluene (300 lit) and water (200 lit) were stirred at room temperature. The mixture was cooled to 20° C., basified with 10% NaOH solution (100 lit) to pH 9-10 and the phases separated. The aqueous layer was extracted with toluene (2×150 lit). The combined organic solutions were washed with water, dried on sodium sulphate, filtered and used for the next step.

Provenance & Evidence