Tetrahydrofuran → HCID 66838732, compound

Participants

Reaction Steps

The molecular sieves were removed by filtration. At a temperature of −60° C. 13 mL of 0.83M 4-fluorophenylmagnesium bromide in THF (10.8 mmol, 2.00 eq) were added. The conversion was determined by TLC (eluent: ethyl acetate/cyclohexane 1+1). The reaction was quenched after 45 minutes by addition of 10 mL of 2.5M aqueous NaOH. The layers were separated and the organic layer was washed twice with 10 mL of 1M aqueous KHSO4, and once with 10 mL of sat. aqueous NaHCO3.

Provenance & Evidence