Hydrochloric Acid → N-[4-({2-[(Azetidin-1-ylcarbonyl)amino]pyridin-4-yl}oxy)-2-fluorophenyl]-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide hydrochloride

Participants

Reaction Steps

N-[4-({2-[(Azetidin-1-ylcarbonyl)amino]pyridin-4-yl}oxy)-2-fluorophenyl]-N′-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide (25.4 mg) was suspended in acetone (0.254 ml). To this was added a 5M hydrochloric acid (0.010 ml) at room temperature, followed by stirring for 3 hr. After adding of acetone (0.127 ml), insoluble matter was collected by filtration and washed with acetone (0.127 ml, twice). This was dried under aeration at room temperature, then hot air-dried at 60° C. to provide the titled compound as white powder (26.5 mg, 97%).

Provenance & Evidence