참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Furaneol | HCID 19309 | — |
| 반응물 | 3,4-Dibromo-5-hydroxyfuran-2(5H)-one | HCID 93559 | — |
| 반응물 | 2-Cyclopenten-1-one, 2-pentyl- | HCID 117549 | — |
| 반응물 | 2-Methoxy-2,4-diphenyl-3(2H)-furanone | HCID 170874 | — |
| 반응물 | Autoinducer 2 | HCID 446576 | — |
| 반응물 | 4-Bromo-5-methoxy-5-(4-methoxyphenyl)furan-2(5H)-one | HCID 4205038 | — |
| 반응물 | 4-{[3-Bromo-2-(4-methoxyphenyl)-5-oxo-2 5-dihydro-2-furanyl]oxy}benzoate | HCID 131730032 | — |
| 생성물 | 4-bromo-5-(4-methoxyphenyl)-2(5H)-furanone | HCID 4089075 | — |
반응 단계
3,4-dibromo-5-hydroxy-2(5H)-furanone (manufactured by SIGMA), Compound 3: 4-bromo-5-methoxy-5-(4-methoxyphenyl)-2(5H)-furanone (manufactured by SIGMA), and Compound 4: 4-{[3-bromo-2-(4-methoxyphenyl)-5-oxo-2,5-dihydro-2-furanyl]oxy}benzoate (manufactured by SIGMA) were used as test drugs. As positive controls, three (3) kinds of known compounds as an AI-2 inhibitory compounds, such as Compound 5: 4-hydroxy-2,5-dimethyl-3(2H)-furanone (manufactured by SIGMA), Compound 6: 2-methoxy-2,4-diphenyl-3(2H)-furanone (manufactured by SIGMA), and Compound 7: 2-pentyl-2-cyclopentene-1-one (manufactured by SIGMA) were used (see Bassseler et al., Bacteriol. 179, p. 4043-4045, 1997; Yoshida A. et al., Appl. Environ. Microbiol., 71(5), p. 2372-2380, 2005; and Wen Z. T. et al., J. Bacteriol., 189(9), p. 2682-2691, 2004).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08293478B2 |
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| 출처 데이터셋 | uspto-grants-2012_10 |
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| ORD ID | ord-d895693388984e2493ef9aff8b5867f2 |
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| 출처 메모 | uspto-grants-2012_10 |
|---|
