Acetyl chloride → 3-Hydroxyacetanilide

HRID 2066382Notes

Reaction equation

[NH2:1][C:2]1[CH:3]=[C:4]([OH:8])[CH:5]=[CH:6][CH:7]=1.[C:9](Cl)(=[O:11])[CH3:10]>>[OH:8][C:4]1[CH:3]=[C:2]([NH:1][C:9](=[O:11])[CH3:10])[CH:7]=[CH:6][CH:5]=1

Participants

Reactant 2

HCID 6367Acetyl chloride

HCID 115683-Aminophenol

Product 1

HCID 121243-HydroxyacetanilideYield 56.7%

Procedure

By using 3-aminophenol (1.0 g) and acetyl chloride (359 mg) as starting materials, the title compound (392 mg) was obtained in the same manner as that of Reference Example 18.

Sources & evidence

ORD record: ord-c9e6e2f3518d43308c794fd8c6590be6
Source dataset: uspto-grants-2012_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08293715B2

Reaction notes

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