3-Hydroxyacetophenone → HCID 67387300, compound

HRID 2066395Notes

Reaction equation

HRID 2066395 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([C:8](=[O:10])[CH3:9])[CH:5]=[CH:6][CH:7]=1.[CH:11]1([Mg]Cl)[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1>C(OCC)C>[CH:11]1([C:8]([C:4]2[CH:3]=[C:2]([OH:1])[CH:7]=[CH:6][CH:5]=2)([OH:10])[CH3:9])[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1

Participants

4

Reactant 2

HCID 84873-HydroxyacetophenoneHCID 178478990HCID 178478990, compound

Product 1

HCID 67387300HCID 67387300, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

By using 3′-hydroxyacetophenone (200 mg) and a 2 M solution of cyclohexylmagnesium chloride in diethyl ether (2.2 ml) as starting materials, the title compound (69.6 mg) was obtained in the same manner as that of Reference Example 69.

Sources & evidence

ORD record
ord-cabab7c7192d4193b431cc7b9093566f
Source dataset
uspto-grants-2012_10
Patent number
US08293715B2

Reaction notes

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