9-Bromo-[1,2,4]triazolo[1,5-c]quinazolin-5(6H)-one → HCID 178434566, compound

HRID 2066400Notes

Reaction equation

HRID 2066400 reaction equation
[Br:1][C:2]1[CH:11]=[CH:10][C:9]2[NH:8]C(=O)[N:6]3[N:13]=[C:14]([CH3:16])[N:15]=[C:5]3[C:4]=2[CH:3]=1.BrC1C=CC2NC(=O)N3N=CN=C3C=2C=1>>[Br:1][C:2]1[CH:11]=[CH:10][C:9]([NH2:8])=[C:4]([C:5]2[NH:6][N:13]=[C:14]([CH3:16])[N:15]=2)[CH:3]=1

Participants

3

Reactant 2

HCID 1357668559-Bromo-[1,2,4]triazolo[1,5-c]quinazolin-5(6H)-oneHCID 1359762779-bromo-2-methyl-6H-[1,2,4]triazolo[1,5-c]quinazolin-5-one

Product 1

HCID 178434566HCID 178434566, compoundYield 99%

Procedure

As described for example 23c) 9-bromo-2-methyl-6H-[1,2,4]triazolo[1,5-c]quinazolin-5-one (28.5 g, 102 mmol), instead of 9-bromo-6H-[1,2,4]triazolo[1,5-c]quinazolin-5-one, was converted to the title compound (25.5 g, 99%) which was obtained as an off-white solid. MS: m/e=251.0/253.1 [M−H]−.

Sources & evidence

ORD record
ord-43c158abfda64ec1b5fa50ac17d9fbe7
Source dataset
uspto-grants-2012_10
Patent number
US08293730B2

Reaction notes

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