9-Bromo-[1,2,4]triazolo[1,5-c]quinazolin-5(6H)-one → HCID 178434587, compound

HRID 2066401Notes

Reaction equation

HRID 2066401 reaction equation
[Cl:1][C:2]1[CH:11]=[CH:10][C:9]2[NH:8]C(=O)[N:6]3[N:13]=[C:14]([CH3:16])[N:15]=[C:5]3[C:4]=2[CH:3]=1.BrC1C=CC2NC(=O)N3N=CN=C3C=2C=1>>[Cl:1][C:2]1[CH:11]=[CH:10][C:9]([NH2:8])=[C:4]([C:5]2[NH:6][N:13]=[C:14]([CH3:16])[N:15]=2)[CH:3]=1

Participants

3

Reactant 2

HCID 1357668559-Bromo-[1,2,4]triazolo[1,5-c]quinazolin-5(6H)-oneHCID 1359762939-Chloro-2-methyl-[1,2,4]triazolo[1,5-c]quinazolin-5(6H)-one

Product 1

HCID 178434587HCID 178434587, compoundYield 76.4%

Procedure

As described for example 23c) 9-chloro-2-methyl-6H-[1,2,4]triazolo[1,5-c]quinazolin-5-one (9.67 g, 41.2 mmol), instead of 9-bromo-6H-[1,2,4]triazolo[1,5-c]quinazolin-5-one, was converted to the title compound (6.57 g, 76%) which was obtained as an off-white solid. MS: m/e=209.0 [M+H]+.

Sources & evidence

ORD record
ord-1d0a37e1a1474f1ebafb7804db852edf
Source dataset
uspto-grants-2012_10
Patent number
US08293730B2

Reaction notes

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