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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2066403Generated: October 31, 2026

9-Bromo-[1,2,4]triazolo[1,5-c]quinazolin-5(6H)-one → 4-Trifluoromethoxy-2-(2H-[1,2,4]triazol-3-yl)-phenylamine

https://huagongshe.com/reaction/2066403

Reaction equation

Participants

RoleNameHCIDCharge
Reactant9-Bromo-[1,2,4]triazolo[1,5-c]quinazolin-5(6H)-oneHCID 135766855—
Reactant9-trifluoromethoxy-6H-[1,2,4]triazolo[1,5-c]quinazolin-5-oneHCID 136333082—
Product4-Trifluoromethoxy-2-(2H-[1,2,4]triazol-3-yl)-phenylamineHCID 6869722265%

Reaction Steps

As described for example 23c) 9-trifluoromethoxy-6H-[1,2,4]triazolo[1,5-c]quinazolin-5-one (5.51 g, 20.4 mmol), instead of 9-bromo-6H-[1,2,4]triazolo[1,5-c]quinazolin-5-one, was converted to the title compound (3.22 g, 65%) which was obtained as a light brown solid. MS: m/e=245.2 [M+H]+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08293730B2
Source datasetuspto-grants-2012_10
ORD IDord-693718fd7776458ab6080e14400514e3
Source noteuspto-grants-2012_10