Sodium hydride → HCID 58054334, compound

Participants

Reaction Steps

To a suspension of sodium hydride (0.327 g, 8.18 mmol) in DMF (31 mL) at 0° C. was added 1-tert-Butoxycarbonyl-4-hydroxypiperidine (1.266 g, 6.29 mmol). After 10 min, 4-(8-bromo-2-chloro-9-methyl-9H-purin-6-yl)morpholine (2.09 g, 6.29 mmol) was added. The mixture was stirred at rt for 3 h. Diluted with EtOAc, the mixture was washed with ½ brine (2×), brine, and dried (Na2SO4). The crude (3.075 g) was used directly for further transformations. LCMS: M+H+=453.4.

Provenance & Evidence