Hydrochloric Acid → HCID 54597140, compound

Participants

Reaction Steps

A suspension of Example 1E (45 mg, 0.081 mmol) in ethanol (6 ml) was treated with 2 ml of a 6N HCl solution, refluxed for 1 hour, then cooled and concentrated to near dryness. The residue was triturated with water and the resulting solid was collected, dissolved in methanol and CH2Cl, adsorbed onto Celite, and purified by silica gel chromatography (4% methanol in CH2Cl2) to afford the title compound. 1H NMR (300 MHz, DMSO-d6) δ ppm 3.94 (s, 3 H) 6.79 (dt, J=8.82 Hz, 2.37 Hz, 1 H) 7.15 (d, J=8.14 Hz, 1 H) 7.32 (q, J=8.14 Hz, 1 H) 7.45 (dd, J=8.48 Hz, 1.36 Hz, 1 H) 7.51 (dt, J=2.37 Hz, 11.87 Hz, 1 H) 7.59 (m, 2 H) 7.69 (m, 3 H) 7.99 (s, 1 H) 8.05 (d, J=8.48 Hz, 1 H) 8.37 (s, 1 H) 8.89 (s, 1 H) 8.96 (s, 1 H) 12.94 (s, 1 H). MS (ESI(+)) m/e 427 (M+H)+.

Provenance & Evidence