HRID2066471

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID53439217

tert-Butyl 1-oxa-4,9-diazaspiro[5.5]undecane-4-carboxylate

C13H24N2O3

结构：CC(C)(C)OC(=O)N1CCC2(CC1)CN(Cc1cc3nc(Cl)nc(N4CCOCC4)c3s1)CCO2

HCID58117135

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)N1CCOC2(CCN(Cc3cc4nc(Cl)nc(N5CCOCC5)c4s3)CC2)C1

HCID58117065

未命名化合物

PROCEDURE

实验过程

Prepared according to the method used in the preparation of 4-(2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-1-oxa-4,9-diaza-spiro[5.5]undecane-9-carboxylic acid tert-butyl ester using 1-oxa-4,9-diaza-spiro[5.5]undecane-4-carboxylic acid tert-butyl ester in place of 4-ethoxy-4-methylaminomethyl-piperidine-1-carboxylic acid tert-butyl ester. The title compound was obtained as a white solid (110 mg, 60%).

WORKUP

后处理

customPrepared

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d4d75730d1ab4577a291062de308ace6
来源数据集: uspto-grants-2012_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08293735B2
来源说明: uspto-grants-2012_10

反应 SMILES

C(OC(N1CCC2(OCCN([CH2:17][C:18]3[S:26][C:25]4[C:24]([N:27]5[CH2:32][CH2:31][O:30][CH2:29][CH2:28]5)=[N:23][C:22]([Cl:33])=[N:21][C:20]=4[CH:19]=3)C2)CC1)=O)(C)(C)C.[C:36]([O:40][C:41]([N:43]1[CH2:48][C:47]2([CH2:53][CH2:52][NH:51][CH2:50][CH2:49]2)[O:46][CH2:45][CH2:44]1)=[O:42])([CH3:39])([CH3:38])[CH3:37]>>[C:36]([O:40][C:41]([N:43]1[CH2:48][C:47]2([CH2:53][CH2:52][N:51]([CH2:17][C:18]3[S:26][C:25]4[C:24]([N:27]5[CH2:32][CH2:31][O:30][CH2:29][CH2:28]5)=[N:23][C:22]([Cl:33])=[N:21][C:20]=4[CH:19]=3)[CH2:50][CH2:49]2)[O:46][CH2:45][CH2:44]1)=[O:42])([CH3:39])([CH3:37])[CH3:38]