tert-Butyl 1-oxa-4,9-diazaspiro(5.5)undecane-4-carboxylate → 9-(2-Chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-1-oxa-4,9-diaza-spiro[5.5]undecane-4-carboxylic acid tert-butyl ester

HRID 2066471Notes

Reaction equation

HRID 2066471 reaction equation
C(OC(N1CCC2(OCCN([CH2:17][C:18]3[S:26][C:25]4[C:24]([N:27]5[CH2:32][CH2:31][O:30][CH2:29][CH2:28]5)=[N:23][C:22]([Cl:33])=[N:21][C:20]=4[CH:19]=3)C2)CC1)=O)(C)(C)C.[C:36]([O:40][C:41]([N:43]1[CH2:48][C:47]2([CH2:53][CH2:52][NH:51][CH2:50][CH2:49]2)[O:46][CH2:45][CH2:44]1)=[O:42])([CH3:39])([CH3:38])[CH3:37]>>[C:36]([O:40][C:41]([N:43]1[CH2:48][C:47]2([CH2:53][CH2:52][N:51]([CH2:17][C:18]3[S:26][C:25]4[C:24]([N:27]5[CH2:32][CH2:31][O:30][CH2:29][CH2:28]5)=[N:23][C:22]([Cl:33])=[N:21][C:20]=4[CH:19]=3)[CH2:50][CH2:49]2)[O:46][CH2:45][CH2:44]1)=[O:42])([CH3:39])([CH3:37])[CH3:38]

Participants

3

Reactant 2

HCID 53439217tert-Butyl 1-oxa-4,9-diazaspiro(5.5)undecane-4-carboxylateHCID 581171354-(2-Chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-1-oxa-4,9-diaza-spiro[5.5]undecane-9-carboxylic acid tert-butyl ester

Product 1

HCID 581170659-(2-Chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-1-oxa-4,9-diaza-spiro[5.5]undecane-4-carboxylic acid tert-butyl ester

Procedure

Prepared according to the method used in the preparation of 4-(2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-1-oxa-4,9-diaza-spiro[5.5]undecane-9-carboxylic acid tert-butyl ester using 1-oxa-4,9-diaza-spiro[5.5]undecane-4-carboxylic acid tert-butyl ester in place of 4-ethoxy-4-methylaminomethyl-piperidine-1-carboxylic acid tert-butyl ester. The title compound was obtained as a white solid (110 mg, 60%).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-d4d75730d1ab4577a291062de308ace6
Source dataset
uspto-grants-2012_10
Patent number
US08293735B2

Reaction notes

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