HuagongsheHuagongshe Chemistry Print Report · For research reference only
Azetidine hydrochloride → 6-(4-Azetidin-1-yl-piperidin-1-ylmethyl)-2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Azetidine hydrochloride | HCID 12308726 | — |
| Reactant | [1-(2-Chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-piperidin-4-yl]-cyclopropylmethyl-amine | HCID 58117134 | — |
| Product | 6-(4-Azetidin-1-yl-piperidin-1-ylmethyl)-2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidine | HCID 58117140 | — |
Reaction Steps
Prepared according to the method used in the preparation of [1-(2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-piperidin-4-yl]-cyclopropylmethyl-amine using azetidine hydrochloride in place of cyclopropanemethylamine. The title compound was obtained as an orange solid (102 mg, 57%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08293735B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-a66c5d2dbdf342d1bcd6d53202fafee1 |
| Source note | uspto-grants-2012_10 |