Cyclopropylamine → [1-(2-Chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-piperidin-4-yl]-cyclopropyl-amine

HRID 2066476Notes

Reaction equation

HRID 2066476 reaction equation
[Cl:1][C:2]1[N:3]=[C:4]([N:23]2[CH2:28][CH2:27][O:26][CH2:25][CH2:24]2)[C:5]2[S:10][C:9]([CH2:11][N:12]3[CH2:17][CH2:16][CH:15]([NH:18]CC4CC4)[CH2:14][CH2:13]3)=[CH:8][C:6]=2[N:7]=1.[CH:29]1(N)[CH2:31][CH2:30]1>>[Cl:1][C:2]1[N:3]=[C:4]([N:23]2[CH2:28][CH2:27][O:26][CH2:25][CH2:24]2)[C:5]2[S:10][C:9]([CH2:11][N:12]3[CH2:17][CH2:16][CH:15]([NH:18][CH:29]4[CH2:31][CH2:30]4)[CH2:14][CH2:13]3)=[CH:8][C:6]=2[N:7]=1

Participants

3

Reactant 2

HCID 69828CyclopropylamineHCID 58117134[1-(2-Chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-piperidin-4-yl]-cyclopropylmethyl-amine

Product 1

HCID 58117136[1-(2-Chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-piperidin-4-yl]-cyclopropyl-amine

Procedure

Prepared according to the method used in the preparation of [1-(2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-piperidin-4-yl]-cyclopropylmethyl-amine using cyclopropylamine in place of cyclopropanemethylamine. The title compound was obtained as a pale yellow solid (38 mg, 17%).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-4bf9dadd0cee430e8d69ef941c2adfb5
Source dataset
uspto-grants-2012_10
Patent number
US08293735B2

Reaction notes

Loading…